The Science Behind DoseMeRx.

Bayesian dosing, from Research to Clinical Practice.

How does Bayesian Dosing work?

Bayesian dosing uses patient data and laboratory results to estimate a patient’s ability to absorb, process, and clear a drug from their system. Using a published population model, DoseMeRx algorithms adjusts the pharmacokinetic and/or pharmacodynamic parameters so that a patient-specific, individualized drug model is built. This individual model is then used to provide a patient-specific dosing recommendation to reach a therapeutic target.

Where there is no laboratory results yet available, DoseMeRx can use a population model with individual patient details (age, height, weight, sex, even genotype if available) to calculate an initial dose estimate.

Where has it been used?

Bayesian dose forecasting has been used extensively around the world, although its use in a clinical setting has been previously isolated to pockets of clinicians who were familiar with the technology and had a good understanding of both IT and mathematics.

DoseMeRx no longer requires users to be Bayesian experts, making it easy for clinicians to use, and allows for a collaborative team approach to therapy that can be implemented out of the box.

Why should you choose DoseMeRx?

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Here’s how we’ve been able to help others

“The DoseMeRx pharmacokinetic platform has revolutionized the way our institution’s pharmacists provide a pharmacokinetic service for our providers. From the aminoglycoside models to the vancomycin AUC/MIC models, the degree of precision these provide has been really extraordinary. If you are considering a Bayesian-based pharmacokinetic modeling service, I definitely recommend going with DoseMeRx!”

Rebeca Calderon, PharmD | Pharmacy Clinical Specialist, Infectious Diseases & Co-lead, Pediatric Antimicrobial Stewardship Program

Nicklaus Children’s Hospital

“I have been utilizing the Bayesian dosing software DoseMeRx to dose vancomycin for over two years. DoseMeRx has helped provide optimal care for my patients by reducing incidence of acute kidney injury. As a clinical pharmacy specialist, I appreciate the flexible timing of levels and the reduction in inappropriate or uninterpretable drug concentrations. I also appreciate the model fit indicator that shows how well the model fits each individual patient.”

Elizabeth W. Covington, PharmD, BCIDP | Clinical Pharmacy Specialist

“We have been using DoseMeRx for almost a year now. During this period, we noticed a 70% decrease in the rate of kidney injury. This was an important result and based on this, DoseMeRx demonstrated an important cost-effectiveness even in regions with limited resources, mainly due to the shorter hospitalization time. In addition, the flexible sample collection schedule improved the dynamics between all teams involved in TDM (lab, nurses, clinical pharmacists, and infectious diseases specialists).”

Joao Paulo Telles, MD, PhD | Infectious Diseases Specialist

A.C.Camargo Cancer Center

“I can’t thank you enough for showing us this awesome tool. I have not had to document a single ADE from vancomycin since the rollout of DoseMeRx. Also your support team is amazing. I have had many occurrences where I come into the hospital and the night shift tells me that DoseMeRx answered us at two in the morning and they responded in less than two minutes! They are so quick and kudos to them for ensuring our whole team is supported.”

Laura Nelson, PharmD | Clinical Pharmacist, Infectious Diseases

Integris Health

“DoseMeRx has been excellent for us thus far and provides an easy way to calculate AUC dosing.”

Chad Signorelli, PharmD | Lead Clinical Pharmacist

Lompoc Valley Medical Center

“I like that they contact me for input on upgrades to the system. This really gives buy in to the product because I feel like they help make improvements based on real customer feedback.”

Renee Klingler | Lead Clinical Pharmacist

Sarah Bush Lincoln Health System

“I like the ability to better manage my lab draws and dosing times. They’re also a good crew to work with.”

Don Schaeffer

Taylorville Memorial Hospital

“DoseMeRx is very easy to use and we are seeing very good results with our patients. We particularly like the ability to keep multiple courses stacked under one patient to look back on previous regimens. The graphs are easy to read as well.”

Renee Klingler | Lead Clinical Pharmacist

Sarah Bush Lincoln Health System

“I really can’t stress enough how happy we are with our decision to utilize a Bayesian support tool and specifically DoseMeRx. They were instrumental in the implementation of AUC dosing.”

Dustin Orvin, PharmD, BCPS | Clinical Pharmacy Specialist

St. Joseph’s/Candler

“Easy to use and effective. Team is prompt, responsive and customer focused.”

Tony Lai, BPharm, GradDipClinPharm, MClinPharm, MSHPA | Senior Pharmacist

The Children’s Hospital at Westmead, Australia

“I’m excited in this modern era that Bayesian dosing software like DoseMeRx makes it possible to apply best clinical practices at the bedside.”

Tom Lodise, PharmD, PhD | DoseMe Clinical Advisory Board Past Chair, Professor

Albany College of Pharmacy and Health Sciences

“I have been very pleased with the support provided by the DoseMeRx team. They provided us with ample background data, frequent live training sessions, and prompt on-demand support, even on evenings and weekends.”

Robert Smith, PharmD, BCGP, BCPS, FASCP | Senior Director of Health Outcomes and Research

Neil Medical Group

“It’s a straight-forward way to implement AUC-based decision making in vancomycin dosing whilst at the same time minimizing the number of levels needed. It’s a win-win… DoseMeRx solves my need.”

William L. Musick, PharmD, BCPS | Infectious Diseases Clinical Specialist

Houston Methodist