Vancomycin Dosing – The Ultimate List of Vancomycin AUC Resources & Literature

This AUC-focused vancomycin literature review summarizes research evaluating AUC-dosing strategies shown to enhance patient outcomes, reduce adverse drug events and lower healthcare costs. It is intended to serve as a reference point for pharmacists looking for trustworthy and credible literature on this topic.

Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists | Published 19 March 2020
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Clinical Effectiveness of AUC Vancomycin Dosing

Research articles regarding enhanced outcomes associated with AUC-based monitoring of vancomycin.

DoseMeRx increases the proportion of vancomycin patients achieving target AUC₂₄ and the percentage in target therapeutic range
Authors: Luqman Vali, David R Jenkins, Rakesh Vaja, Hussain Mulla | Download Paper

Impact of source of infection and vancomycin AUC0-24/MIC_BMD targets on treatment failure in patients with methicillin-resistant Staphylococcus aureus bacteraemia.
Authors: Ghosh N, Chavada R, Maley M, van Hal SJ. | Download Paper

Are vancomycin trough concentrations adequate for optimal dosing?
Authors: Neely MN, Youn G, Jones B, et al. | Download Paper

Are vancomycin trough concentrations of 15 to 20 mg/L associated with increased attainment of an AUC/MIC ≥ 400 in patients with presumed MRSA infection?
Authors: Hale CM, Seabury RW, Steele JM, Darko W, Miller CD. | Download Paper

Association between the AUC0-24/MIC ratio of vancomycin and its clinical effectiveness: a systematic review and meta-analysis.
Authors: Men P, Li HB, Zhai SD, Zhao RS. | Download Paper

Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections.
Authors: Moise-Broder PA, Forrest A, Birmingham MC, Schentag JJ. | Download Paper

Examining the relationship between vancomycin area under the concentration time curve and serum trough levels in adults with presumed or documented Staphylococcal infections.
Authors: Clark L, Skrupky LP, Servais R, Brummitt CF, Dilworth TJ. | Download Paper

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia.
Authors: Holmes NE, Turnidge JD, Munckhof WJ, et al. | Download Paper

Vancomycin trough concentration as a predictor of clinical outcomes in patients with Staphylococcus aureus bacteremia: a meta-analysis of observational studies.
Authors: Prybylski JP. | Download Paper

Making the change to area under the curve-based vancomycin dosing.
Authors: Heil EL, Claeys KC, et al | Download Paper

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia.
Authors: Holmes NE, Turnidge JD, Munckhof WJ, et al. | Download Paper

Vancomycin Area Under the Curve–Guided Dosing and Monitoring for Adult and Pediatric Patients With Suspected or Documented Serious Methicillin-Resistant Staphylococcus aureus Infections: Putting the Safety of Our Patients First.
Authors: Lodise T, Drusano G. | Download Paper

The case for precision dosing: medical conservatism does not justify inaction.
Authors: Scheetz M, Lodise T, Downes K, et al. | Download Editorial

Vancomycin Area Under the Curve-guided Dosing and Monitoring: Is the Juice Worth the Squeeze”?
Authors: Lodise T, Hall R, Scheetz M | Download Editorial

Increased proportion of pediatric patients in therapeutic range/AUC

Improved vancomycin dosing in children using area under the curve exposure.
Authors: Le J, Bradley JS, Murray W, et al. | Download Paper

Early Bayesian dose adjustment of vancomycin continuous infusion in children: a randomized controlled trial.
Authors: Berthaud R, Benaboud S, Hirt D, et al. | Download Paper

Optimal vancomycin dosing in obesity

Population pharmacokinetics of vancomycin in obesity: finding the optimal dose for (morbidly) obese individuals.
Authors: Smit C, Wasmann RE, Goulooze SC, et al. | Download Paper

An AUC target simulation for vancomycin in patients with class III obesity.
Authors: Langton MM, Ahern JW, MacDougall J. | Download Paper

AUC-based monitoring results in fewer dose adjustments

The impact of AUC-based monitoring on pharmacist-directed vancomycin dose adjustments in complicated methicillin-resistant Staphylococcus aureus infection.
Authors: Stoessel AM, Hale CM, Seabury RW, Miller CD, Steele JM. | Download Paper

Pharmacokinetic modelling for vancomycin

Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current dosing recommendations.
Authors: Colin PJ, Allegaert K, Thomson AH, Touw DJ, Dolton M, de Hoog M, et al. | Download Paper

Towards precision dosing of vancomycin: a systematic evaluation of pharmacometric models for Bayesian forecasting.
Authors: Broeker A, Nardecchia M, Klinker KP, Derendorf H, Day RO, Marriott DJ, et al. | Download Paper

Vancomycin: we can’t get there from here.
Authors: Patel N, Pai MP, Rodvold KA, Lomaestro B, Drusano GL, Lodise TP. | Download Paper

Comparison of the area-under-the-curve for vancomycin estimated using compartmental and non-compartmental methods in adult patients with normal renal function.
Authors: Shingde RV, Graham GG, Reuter SE, Carland JE, Day RO, Stocker SL. | Download Paper

The dosing and monitoring of vancomycin: what is the best way forward?
Authors: Drennan PG, Begg EJ, Gardiner SJ, Kirkpatrick CMJ, Chambers ST. | Download Paper

Reduce adverse events

Research articles regarding the decreased risk of nephrotoxicity associated with AUC-based monitoring of vancomycin.

Vancomycin area under the curve and acute kidney injury: a meta-analysis.
Authors: Aljefri DM, Avedissian SN, Rhodes NJ, Postelnick MJ, Nguyen K, Scheetz MH. | Download Paper

The impact of vancomycin area under the concentration-time curve-guided dosing on vancomycin-associated nephrotoxicity: a quasi-experiment.
Authors: Finch NA, Zasowski EJ, Murray KP, et al. | Download Paper

Navigating the Muddy Waters of Vancomycin Nephrotoxicity.
Authors: Barreto, EF, et al. | Download Paper

Reduce costs

AUC-guided vancomycin dosing has the potential for substantial cost savings due to associations with decreased nephrotoxicity, reduced per-patient blood sampling and decreased length of therapy.

AUC24 Vancomycin Bayesian-based dosing: Increasing Therapeutic Target Attainment with Decreased Monitoring Costs
Authors: Sabourenkov P, McLeay R. | Download Paper

Prospective trial on the use of trough concentration versus area under the curve to determine therapeutic vancomycin dosing.
Authors: Neely MN, Kato L, Youn G, et al. | Download Paper

Implementation

Research articles regarding the implementation of AUC-based monitoring of vancomycin.

Vancomycin area under the curve dosing and monitoring at an academic medical center: transition strategies and lessons learned.
Authors: Gregory ER, Burgess DR, Cotner SE, et al. | Download Paper

Readiness to implement vancomycin monitoring based on area under the concentration-time curve: a cross-sectional survey of a national health consortium.
Authors: Kufel WD, Seabury RW, Mogle BT, Beccari MV, Probst LA, Steele JM. | Download Paper

Conversion from vancomycin trough concentration-guided dosing to area under the curve-guided dosing using two sample measurements in adults: implementation at an academic medical center.
Authors: Meng L, Wong T, Huang S, et al. | Download Paper

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